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The .375 H&H Magnum has been around since 1912, and can be used to hunt any and everything, from elephants to grizzly bears. Find yours at https://snp.link/36ca10b3.
One of Tom's all-time favorite cartridges... the .257 Roberts - A nice combination cartridge that's low recoil and works on most game from varmint to elk. Find it at https://snp.link/0bb00360.
The .280 Remington cartridge has survived a name change and lack of star power - If you've never considered it, give it a second look!
Kevin "KJ" Jarnagin went on an epic North American big game hunt, including elk and black bear in Canada, using only one cartridge - Black Hills Ammunition's 143 grain ELD-X in 6.5 Creedmoor.